GIPC3 couples to MYO6 and PDZ domain proteins and shapes the hair cell apical region.

ABSTRACT: GIPC3 has been implicated in auditory function. Initially localized to the cytoplasm of inner and outer hair cells of the cochlea, GIPC3 increasingly concentrated in cuticular plates and at cell junctions during postnatal development. Early postnatal Gipc3 ^KO/KO mice had mostly normal mechanotransduction currents, but had no auditory brainstem response at one month of age. Cuticular plates of Gipc3 ^KO/KO hair cells did not flatten during development as did those of controls; moreover, hair bundles were squeezed along the cochlear axis in mutant hair cells. Junctions between inner hair cells and adjacent inner phalangeal cells were also severely disrupted in Gipc3 ^KO/KO cochleas. GIPC3 bound directly to MYO6, and the loss of MYO6 led to

SUBMITTER: Chatterjee P 

PROVIDER: S-EPMC10002731 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature