Differential cognitive effects of unilateral left and right subthalamic nucleus deep brain stimulation for Parkinson disease.

ABSTRACT:

Objective

To investigate hemispheric effects of directional versus ring subthalamic nucleus (STN) deep brain stimulation (DBS) surgery on cognitive function in patients with advanced Parkinson's disease (PD).

Methods

We examined 31 PD patients (Left STN n = 17; Right STN n = 14) who underwent unilateral subthalamic nucleus (STN) DBS as part of a NIH-sponsored randomized, cross-over, double-blind (ring vs directional) clinical trial. Outcome measures were tests of verbal fluency, auditory-verbal memory, and response inhibition. First, all participants were pooled together to study the effects of directional versus ring stimulation. Then, we stratified the groups by surgery hemisphere and studied the longitudinal changes in cognition post-unilateral STN DBS.

Results

Rel

SUBMITTER: Del Bene VA 

PROVIDER: S-EPMC10002774 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature