Heteromerization of Dopamine D2 and Oxytocin Receptor in Adult Striatal Astrocytes.

ABSTRACT: The ability of oxytocin (OT) to interact with the dopaminergic system through facilitatory D2-OT receptor (OTR) receptor-receptor interaction in the limbic system is increasingly considered to play roles in social or emotional behavior, and suggested to serve as a potential therapeutic target. Although roles of astrocytes in the modulatory effects of OT and dopamine in the central nervous system are well recognized, the possibility of D2-OTR receptor-receptor interaction in astrocytes has been neglected. In purified astrocyte processes from adult rat striatum, we assessed OTR and dopamine D2 receptor expression by confocal analysis. The effects of activation of these receptors were evaluated in the processes through a neurochemical study of glutamate release evoked by 4-aminopyridine; D2-O

SUBMITTER: Amato S 

PROVIDER: S-EPMC10002782 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature