Endothelin-1 Induces Cell Proliferation and Myofibroblast Differentiation through the ET_AR/G_αq/ERK Signaling Pathway in Human Cardiac Fibroblasts.

ABSTRACT: Endothelin-1 (ET-1) has been implicated in the pathogenesis of cardiac fibrosis. Stimulation of endothelin receptors (ETR) with ET-1 leads to fibroblast activation and myofibroblast differentiation, which is mainly characterized by an overexpression of α-smooth muscle actin (α-SMA) and collagens. Although ET-1 is a potent profibrotic mediator, the signal transductions and subtype specificity of ETR contributing to cell proliferation, as well as α-SMA and collagen I synthesis in human cardiac fibroblasts are not well clarified. This study aimed to evaluate the subtype specificity and signal transduction of ETR on fibroblast activation and myofibroblast differentiation. Treatment with ET-1 induced fibroblast proliferation, and synthesis of myofibroblast markers, α-SMA, and collagen I through

SUBMITTER: Duangrat R 

PROVIDER: S-EPMC10002923 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature