Proline-rich polypeptides (Colostrinin^®/COLOCO^®) modulate BDNF concentration in blood affecting cognitive function in adults: A double-blind randomized placebo-controlled study.

ABSTRACT: Proline-rich polypeptides (PRPs complex also known as COLOCO^®, Colostrinin^®) consist of low-molecular weight peptides ranging up to 10 kDa, isolated from the bovine colostrum obtained up to 48 h postpartum. PRPs have been shown to affect processes involved in inflammation, brain aging, and neurodegeneration. The aim of this study was to investigate the effect of Colostrinin^® (COLOCO^®) on the cognitive abilities of healthy volunteers in three different age groups using the CANTAB tool in a double-blind randomized placebo-controlled study. BDNF serum level was used as a physicochemical marker of improvement of the cognitive skills. Three hundred and sixty-one healthy volunteers were divided into three study groups aged 18-24, 25-54, and 55-75; each

SUBMITTER: Banasiak-Cieslar H 

PROVIDER: S-EPMC10002942 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature