A Novel Early Life Stress Model Affects Brain Development and Behavior in Mice.

ABSTRACT: Early life stress (ELS) in developing children has been linked to physical and psychological sequelae in adulthood. In the present study, we investigated the effects of ELS on brain and behavioral development by establishing a novel ELS model that combined the maternal separation paradigm and mesh platform condition. We found that the novel ELS model caused anxiety- and depression-like behaviors and induced social deficits and memory impairment in the offspring of mice. In particular, the novel ELS model induced more enhanced depression-like behavior and memory impairment than the maternal separation model, which is the established ELS model. Furthermore, the novel ELS caused upregulation of arginine vasopressin expression and downregulation of GABAergic interneuron markers, such as parval

SUBMITTER: Shin HS 

PROVIDER: S-EPMC10002977 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature