Impact of Negative Feedbacks on De Novo Pyrimidines Biosynthesis in Escherichia coli.

ABSTRACT: Earlier studies aimed at investigating the metabolism of endogenous nucleoside triphosphates in synchronous cultures of E. coli cells revealed an auto-oscillatory mode of functioning of the pyrimidine and purine nucleotide biosynthesis system, which the authors associated with the dynamics of cell division. Theoretically, this system has an intrinsic oscillatory potential, since the dynamics of its functioning are controlled through feedback mechanisms. The question of whether the nucleotide biosynthesis system has its own oscillatory circuit is still open. To address this issue, an integral mathematical model of pyrimidine biosynthesis was developed, taking into account all experimentally verified negative feedback in the regulation of enzymatic reactions, the data of which were ob

SUBMITTER: Akberdin IR 

PROVIDER: S-EPMC10003070 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature