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Synthesis of Ester-Containing Chroman-4-Ones via Cascade Radical Annulation of 2-(Allyloxy)Arylaldehydes with Oxalates under Metal Free Conditions.

ABSTRACT: A convenient and practical method for the synthesis of bioactive ester-containing chroman-4-ones through the cascade radical cyclization of 2-(allyloxy)arylaldehydes and oxalates is described. The preliminary studies suggest that an alkoxycarbonyl radical might be involved in the current transformation, which was generated via the decarboxylation of oxalates in the presence of (NH₄)₂S₂O₈.

SUBMITTER: Peng S

PROVIDER: S-EPMC10003100 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature

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Synthesis of Ester-Containing Chroman-4-Ones via Cascade Radical Annulation of 2-(Allyloxy)Arylaldehydes with Oxalates under Metal Free Conditions.

Peng Sha S Liu Jiao J Jiang Ze-Qun ZQ Yuan Lin L Liu Xiao-Wen XW Xie Long-Yong LY

International journal of molecular sciences 20230306 5

A convenient and practical method for the synthesis of bioactive ester-containing chroman-4-ones through the cascade radical cyclization of 2-(allyloxy)arylaldehydes and oxalates is described. The preliminary studies suggest that an alkoxycarbonyl radical might be involved in the current transformation, which was generated via the decarboxylation of oxalates in the presence of (NH4)2S2O8. ...[more]

PMID: 36902464

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