Heterochronic Parabiosis Causes Dacryoadenitis in Young Lacrimal Glands.

ABSTRACT: Aging is associated with inflammation and oxidative stress in the lacrimal gland (LG). We investigated if heterochronic parabiosis of mice could modulate age-related LG alterations. In both males and females, there were significant increases in total immune infiltration in isochronic aged LGs compared to that in isochronic young LGs. Male heterochronic young LGs were significantly more infiltrated compared to male isochronic young LGs. While both females and males had significant increases in inflammatory and B-cell-related transcripts in isochronic and heterochronic aged LGs compared to levels isochronic and heterochronic young LGs, females had a greater fold expression of some of these transcripts than males. Through flow cytometry, specific subsets of B cells were increased in the male

SUBMITTER: Scholand KK 

PROVIDER: S-EPMC10003158 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature