Intracellular Helix-Loop-Helix Domain Modulates Inactivation Kinetics of Mammalian TRPV5 and TRPV6 Channels.

ABSTRACT: TRPV5 and TRPV6 are calcium-selective ion channels expressed at the apical membrane of epithelial cells. Important for systemic calcium (Ca²⁺) homeostasis, these channels are considered gatekeepers of this cation transcellular transport. Intracellular Ca²⁺ exerts a negative control over the activity of these channels by promoting inactivation. TRPV5 and TRPV6 inactivation has been divided into fast and slow phases based on their kinetics. While slow inactivation is common to both channels, fast inactivation is characteristic of TRPV6. It has been proposed that the fast phase depends on Ca²⁺ binding and that the slow phase depends on the binding of the Ca²⁺/Calmodulin complex to the internal gate of the channels. Here, by means of structural analy

SUBMITTER: Flores-Aldama L 

PROVIDER: S-EPMC10003196 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature