Regulation of MAPK Signaling Pathways by the Large HERC Ubiquitin Ligases.

ABSTRACT: Protein ubiquitylation acts as a complex cell signaling mechanism since the formation of different mono- and polyubiquitin chains determines the substrate's fate in the cell. E3 ligases define the specificity of this reaction by catalyzing the attachment of ubiquitin to the substrate protein. Thus, they represent an important regulatory component of this process. Large HERC ubiquitin ligases belong to the HECT E3 protein family and comprise HERC1 and HERC2 proteins. The physiological relevance of the Large HERCs is illustrated by their involvement in different pathologies, with a notable implication in cancer and neurological diseases. Understanding how cell signaling is altered in these different pathologies is important for uncovering novel therapeutic targets. To this end, this review s

SUBMITTER: Sala-Gaston J 

PROVIDER: S-EPMC10003351 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature