Pore-Forming Proteins: From Pore Assembly to Structure by Quantitative Single-Molecule Imaging.

ABSTRACT: Pore-forming proteins (PFPs) play a central role in many biological processes related to infection, immunity, cancer, and neurodegeneration. A common feature of PFPs is their ability to form pores that disrupt the membrane permeability barrier and ion homeostasis and generally induce cell death. Some PFPs are part of the genetically encoded machinery of eukaryotic cells that are activated against infection by pathogens or in physiological programs to carry out regulated cell death. PFPs organize into supramolecular transmembrane complexes that perforate membranes through a multistep process involving membrane insertion, protein oligomerization, and finally pore formation. However, the exact mechanism of pore formation varies from PFP to PFP, resulting in different pore structures with diff

SUBMITTER: Margheritis E 

PROVIDER: S-EPMC10003378 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature