Electrical Remodeling in Right Ventricular Failure Due to Pulmonary Hypertension: Unraveling Novel Therapeutic Targets.

ABSTRACT: Arrhythmias in the setting of right-ventricular (RV) remodeling contribute to majority of deaths in patients with pulmonary hypertension. However, the underlying mechanism of electrical remodeling remains elusive, especially ventricular arrhythmias. Here, we analyzed the RV transcriptome of pulmonary arterial hypertension (PAH) patients with compensated RV or decompensated RV and identified 8 and 45 differentially expressed genes known to be involved in regulating the electrophysiological properties of excitation and contraction of cardiac myocytes, respectively. Transcripts encoding voltage-gated Ca²⁺ and Na⁺ channels were notably decreased in PAH patients with decompensated RV, along with significant dysregulation of K_V and K_ir channels. We fur

SUBMITTER: Park JF 

PROVIDER: S-EPMC10003421 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature