Overexpression of Potential Markers of Regulatory and Exhausted CD8⁺ T Cells in the Peripheral Blood Mononuclear Cells of Patients with B-Acute Lymphoblastic Leukemia.

ABSTRACT: B-acute lymphoblastic leukemia (B-ALL) is one of the most common pediatric cancers, wherein regulatory T cells (Treg) and exhausted CD8⁺ T cells may be important in its development and maintenance. In this bioinformatics study, we evaluated the expression of 20 Treg/CD8 exhaustion markers and their possible roles in patients with B-ALL. The mRNA expression values of peripheral blood mononuclear cell samples from 25 patients with B-ALL and 93 healthy subjects (HSs) were downloaded from publicly available datasets. Treg/CD8 exhaustion marker expression was normalized with that of the T cell signature and correlated with the expression of Ki-67, regulatory transcription factors (FoxP3, Helios), cytokines (IL-10, TGF-β), CD8⁺ markers (CD8α chain, CD8β chain), and CD8

SUBMITTER: Naghavi Alhosseini M 

PROVIDER: S-EPMC10003658 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature