Age-dependent Microglial Disease Phenotype Results in Functional Decline in Gut Macrophages.

ABSTRACT:

Background and aims

Muscularis macrophages (MMs) are tissue-resident macrophages in the gut muscularis externa which play a supportive role to the enteric nervous system. We have previously shown that age-dependent MM alterations drive low-grade enteric nervous system inflammation, resulting in neuronal loss and disruption of gut motility. The current studies were designed to identify the MM genetic signature involved in these changes, with particular emphasis on comparison to genes in microglia, the central nervous system macrophage population involved in age-dependent cognitive decline.

Methods

Young (3 months) and old (16-24 months) C57BL/6 mice and human tissue were studied. Immune cells from mouse small intestine, colon, and spinal cord and human colon were dissociated,

SUBMITTER: Bishop ES 

PROVIDER: S-EPMC10003669 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature