How Does Vitamin D Affect Immune Cells Crosstalk in Autoimmune Diseases?

ABSTRACT: Vitamin D is a secosteroid hormone that is highly involved in bone health. Mounting evidence revealed that, in addition to the regulation of mineral metabolism, vitamin D is implicated in cell proliferation and differentiation, vascular and muscular functions, and metabolic health. Since the discovery of vitamin D receptors in T cells, local production of active vitamin D was demonstrated in most immune cells, addressing the interest in the clinical implications of vitamin D status in immune surveillance against infections and autoimmune/inflammatory diseases. T cells, together with B cells, are seen as the main immune cells involved in autoimmune diseases; however, growing interest is currently focused on immune cells of the innate compartment, such as monocytes, macrophages, dendritic ce

SUBMITTER: Gallo D 

PROVIDER: S-EPMC10003699 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature