Conserved microRNAs and Flipons Shape Gene Expression during Development by Altering Promoter Conformations.

ABSTRACT: The classical view of gene regulation draws from prokaryotic models, where responses to environmental changes involve operons regulated by sequence-specific protein interactions with DNA, although it is now known that operons are also modulated by small RNAs. In eukaryotes, pathways based on microRNAs (miR) regulate the readout of genomic information from transcripts, while alternative nucleic acid structures encoded by flipons influence the readout of genetic programs from DNA. Here, we provide evidence that miR- and flipon-based mechanisms are deeply connected. We analyze the connection between flipon conformation and the 211 highly conserved human miR that are shared with other placental and other bilateral species. The direct interaction between conserved miR (c-miR) and flipons is sup

SUBMITTER: Herbert A 

PROVIDER: S-EPMC10003719 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature