Malaria Control by Mass Drug Administration With Artemisinin Plus Piperaquine on Grande Comore Island, Union of Comoros.

ABSTRACT:

Background

Mass drug administration (MDA) is a powerful tool for malaria control, but the medicines to use, dosing, number of rounds, and potential selection of drug resistance remain open questions.

Methods

Two monthly rounds of artemisinin-piperaquine (AP), each comprising 2 daily doses, were administered across the 7 districts of Grande Comore Island. In 3 districts, low-dose primaquine (PMQ_LD) was also given on the first day of each monthly round. Plasmodium falciparum malaria rates, mortality, parasitemias, adverse events, and genetic markers of potential drug resistance were evaluated.

Results

Average population coverages of 80%-82% were achieved with AP in 4 districts (registered population 258 986) and AP + PMQ_LD in 3 districts (83

SUBMITTER: Deng C 

PROVIDER: S-EPMC10003749 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature