Specificity Proteins (SP) and Kruppel-like Factors (KLF) in Liver Physiology and Pathology.

ABSTRACT: The liver acts as a central hub that controls several essential physiological processes ranging from metabolism to detoxification of xenobiotics. At the cellular level, these pleiotropic functions are facilitated through transcriptional regulation in hepatocytes. Defects in hepatocyte function and its transcriptional regulatory mechanisms have a detrimental influence on liver function leading to the development of hepatic diseases. In recent years, increased intake of alcohol and western diet also resulted in a significantly increasing number of people predisposed to the incidence of hepatic diseases. Liver diseases constitute one of the serious contributors to global deaths, constituting the cause of approximately two million deaths worldwide. Understanding hepatocyte transcriptional mech

SUBMITTER: Yerra VG 

PROVIDER: S-EPMC10003758 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature