Review of Basic Research about Ossification of the Spinal Ligaments Focusing on Animal Models.

ABSTRACT: Ossification of the posterior longitudinal ligament (OPLL) is a heterotopic ossification that may cause spinal cord compression. With the recent development of computed tomography (CT) imaging, it is known that patients with OPLL often have complications related to ossification of other spinal ligaments, and OPLL is now considered part of ossification of the spinal ligaments (OSL). OSL is known to be a multifactorial disease with associated genetic and environmental factors, but its pathophysiology has not been clearly elucidated. To elucidate the pathophysiology of OSL and develop novel therapeutic strategies, clinically relevant and validated animal models are needed. In this review, we focus on animal models that have been reported to date and discuss their pathophysiology and clinical

SUBMITTER: Ikuta M 

PROVIDER: S-EPMC10003841 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature