Profiling of Taxoid Compounds in Plant Cell Cultures of Different Species of Yew (Taxus spp.).

ABSTRACT: Plant cell cultures of various yew species are a profitable source of taxoids (taxane diterpenoids) with antitumor activity. So far, despite intensive studies, the principles of the formation of different groups of taxoids in cultured in vitro plant cells have not been fully revealed. In this study, the qualitative composition of taxoids of different structural groups was assessed in callus and suspension cell cultures of three yew species (Taxus baccata, T. canadensis, and T. wallichiana) and two T. × media hybrids. For the first time, 14-hydroxylated taxoids were isolated from the biomass of the suspension culture of T. baccata cells, and their structures were identified by high-resolution mass spectrometry and NMR spectroscopy as 7β-hydroxy-taxuyunnanin C, si

SUBMITTER: Kochkin DV 

PROVIDER: S-EPMC10004465 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature