BF₂-Azadipyrromethene Fluorophores for Intraoperative Vital Structure Identification.

ABSTRACT: A series of mono- and bis-polyethylene glycol (PEG)-substituted BF₂-azadipyrromethene fluorophores have been synthesized with emissions in the near-infrared region (700-800 nm) for the purpose of fluorescence guided intraoperative imaging; chiefly ureter imaging. The Bis-PEGylation of fluorophores resulted in higher aqueous fluorescence quantum yields, with PEG chain lengths of 2.9 to 4.6 kDa being optimal. Fluorescence ureter identification was possible in a rodent model with the preference for renal excretion notable through comparative fluorescence intensities from the ureters, kidneys and liver. Ureteral identification was also successfully performed in a larger animal porcine model under abdominal surgical conditions. Three tested doses of 0.5, 0.25 and 0.1 mg/kg all succes

SUBMITTER: Caulfield C 

PROVIDER: S-EPMC10004488 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature