Involvement of circulating soluble HLA-G after liver transplantation in the low immunogenicity of hepatic allograft

ABSTRACT: Graft rejection is a critical risk in solid-organ transplantation. To decrease such risk, an understanding of the factors involved in low immunogenicity of liver allografts could potentially make it possible to transfer this tolerogenic property to other transplanted organs. HLA-G, a natural physiological molecule belonging to the Human Leukocyte Antigen class (HLA) Ib family that induces tolerance, is associated with fewer rejections in solid-organ transplantation. In contrast to HLA-G, HLA antigen incompatibilities between donor and recipient can lead to rejection, except in liver transplantation. We compared HLA-G plasma levels and the presence of anti-HLA antibodies before and after LT to understand the low immunogenicity of the liver. We conducted a large prospective study that includ

SUBMITTER: Le Floc’h B 

PROVIDER: S-EPMC10004504 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature