Association between genetic risk of high SBP and hypertension control: the CoLaus|PsyColaus study.

ABSTRACT:

Objective

To assess whether a genetic risk score (GRS) for high SBP is associated with poor control of hypertension.

Methods

Data from the four waves of a population-based, prospective study conducted in Lausanne, Switzerland. Control of hypertension was defined based on SBP less than 140 mmHg and DBP less than 90 mmHg. A weighted GRS was computed from 362 SNPs.

Results

Overall, 1097 (51% men, mean age 61 years), 1126 (53% men, age 65 years), 1020 (52% men, age 69 years) and 809 (50% men, age 71 years) participants treated for hypertension were selected from the baseline (2003-2006), first (2009-2012), second (2014-2017) and third (2018-2021) surveys. Hypertension control rates were 50, 58, 52 and 59% for the baseline, first, second and third surveys, respectively. No

SUBMITTER: Marques-Vidal P 

PROVIDER: S-EPMC10004752 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature