New, Low-Molecular Weight Chemical Compounds Inhibiting Biological Activity of Interleukin 15.

ABSTRACT: Chronic overproduction of IL-15 contributes to the pathogenesis of numerous inflammatory and autoimmune disorders. Experimental methods used to reduce the cytokine activity show promise as potential therapeutic approaches to modify IL-15 signaling and alleviate the development and progression of IL-15-related diseases. We previously demonstrated that an efficient reduction of IL-15 activity can be obtained by selective blocking of the specific, high affinity subunit alpha of the IL-15 receptor (IL-15Rα) with small-molecule inhibitors. In this study, we determined the structure-activity relationship of currently known IL-15Rα inhibitors in order to define the critical structural features required for their activity. To validate our predictions, we designed, analyzed in silico, and assessed

SUBMITTER: Krzeczynski P 

PROVIDER: S-EPMC10005041 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature