Molecular Peptide Grafting as a Tool to Create Novel Protein Therapeutics.

ABSTRACT: The study of peptides (synthetic or corresponding to discrete regions of proteins) has facilitated the understanding of protein structure-activity relationships. Short peptides can also be used as powerful therapeutic agents. However, the functional activity of many short peptides is usually substantially lower than that of their parental proteins. This is (as a rule) due to their diminished structural organization, stability, and solubility often leading to an enhanced propensity for aggregation. Several approaches have emerged to overcome these limitations, which are aimed at imposing structural constraints into the backbone and/or sidechains of the therapeutic peptides (such as molecular stapling, peptide backbone circularization and molecular grafting), therefore enforcing their biolog

SUBMITTER: Komar AA 

PROVIDER: S-EPMC10005171 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature