Integration of reconfigurable microchannels into aligned three-dimensional neural networks for spatially controllable neuromodulation.

ABSTRACT: Anisotropically organized neural networks are indispensable routes for functional connectivity in the brain, which remains largely unknown. While prevailing animal models require additional preparation and stimulation-applying devices and have exhibited limited capabilities regarding localized stimulation, no in vitro platform exists that permits spatiotemporal control of chemo-stimulation in anisotropic three-dimensional (3D) neural networks. We present the integration of microchannels seamlessly into a fibril-aligned 3D scaffold by adapting a single fabrication principle. We investigated the underlying physics of elastic microchannels' ridges and interfacial sol-gel transition of collagen under compression to determine a critical window of geometry and strain. We demonstrated the spatiot

SUBMITTER: Jeong S 

PROVIDER: S-EPMC10005277 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature