The Role of Phytochemicals and Gut Microbiome in Atherosclerosis in Preclinical Mouse Models.

ABSTRACT: Gut microbiome alterations have recently been linked to many chronic conditions including cardiovascular disease (CVD). There is an interplay between diet and the resident gut microbiome, where the food eaten affects populations of certain microbes. This is important, as different microbes are associated with various pathologies, as they can produce compounds that are disease-promoting or disease-protecting. The Western diet negatively affects the host gut microbiome, ultimately resulting in heightened arterial inflammation and cell phenotype changes as well as plaque accumulation in the arteries. Nutritional interventions including whole foods rich in fiber and phytochemicals as well as isolated compounds including polyphenols and traditional medicinal plants show promise in positively in

SUBMITTER: Centner AM 

PROVIDER: S-EPMC10005405 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature