Allostatic load and cardiovascular outcomes in males with prostate cancer.

ABSTRACT:

Background

Cardiovascular disease (CVD) is the leading cause of death in men with prostate cancer (PC). Accumulated stress plays an important role in CVD development. The cumulative burden of chronic stress and life events can be measured using allostatic load (AL).

Methods

The initial cohort included males aged 18 years and older diagnosed with PC (2005-2019). AL was modeled as an ordinal variable (0-11). Fine-Gray competing risk regressions measured the impact of precancer diagnosis AL and postdiagnosis AL in 2-year major cardiac events (MACE). The effect of AL changes over time on MACE development was calculated via piecewise Cox regression (before, and 2 months, 6 months, and 1 year after PC diagnosis).

Results

We included 5261 PC patients of which 6.6% had a 2-ye

SUBMITTER: Stabellini N 

PROVIDER: S-EPMC10005613 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature