Increasing Reaction Rates of Water-Soluble Porphyrins for ⁶⁴Cu Radiopharmaceutical Labeling.

ABSTRACT: Searching for new compounds and synthetic routes for medical applications is a great challenge for modern chemistry. Porphyrins, natural macrocycles able to tightly bind metal ions, can serve as complexing and delivering agents in nuclear medicine diagnostic imaging utilizing radioactive nuclides of copper with particular emphasis on ⁶⁴Cu. This nuclide can, due to multiple decay modes, serve also as a therapeutic agent. As the complexation reaction of porphyrins suffers from relatively poor kinetics, the aim of this study was to optimize the reaction of copper ions with various water-soluble porphyrins in terms of time and chemical conditions, that would meet pharmaceutical requirements and to develop a method that can be applied for various water-soluble porphyrins. In the firs

SUBMITTER: Pegier M 

PROVIDER: S-EPMC10005645 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature