Csf1 from marrow adipogenic precursors is required for osteoclast formation and hematopoiesis in bone.

ABSTRACT: Colony-stimulating factor 1 (Csf1) is an essential growth factor for osteoclast progenitors and an important regulator for bone resorption. It remains elusive which mesenchymal cells synthesize Csf1 to stimulate osteoclastogenesis. We recently identified a novel mesenchymal cell population, marrow adipogenic lineage precursors (MALPs), in bone. Compared to other mesenchymal subpopulations, MALPs expressed Csf1 at a much higher level and this expression was further increased during aging. To investigate its role, we constructed MALP-deficient Csf1 CKO mice using Adipoq^Cre. These mice had increased femoral trabecular bone mass, but their cortical bone appeared normal. In comparison, depletion of Csf1 in the entire mesenchymal lineage using Prrx1

SUBMITTER: Zhong L 

PROVIDER: S-EPMC10005765 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature