Smad4-mediated angiogenesis facilitates the beiging of white adipose tissue in mice.

ABSTRACT: Beige adipocytes are thermogenic with high expression of uncoupling protein 1 in the white adipose tissue (WAT), accompanied by angiogenesis. Previous studies showed that Smad4 is important for angiogenesis. Here we studied whether endothelial Smad4-mediated angiogenesis is involved in WAT beiging. Inducible knockout of endothelial cell (EC) selective Smad4 (Smad4 ^iEC-KO) was achieved by using the Smad4 ^Floxp/floxp and Tie2 ^CreERT2 mice. Beige fat induction achieved by cold or adrenergic agonist, and angiogenesis were attenuated in WAT of Smad4 ^iEC-KO mice, with the less proliferation of ECs and adipogenic precursors. RNA sequencing of human ECs showed that Smad4 is involved in angiogenesis-related

SUBMITTER: Wang C 

PROVIDER: S-EPMC10005906 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature