Functional and molecular characterization of suicidality factors using phenotypic and genome-wide data.

ABSTRACT: Genome-wide association studies (GWAS) of suicidal thoughts and behaviors support the existence of genetic contributions. Continuous measures of psychiatric disorder symptom severity can sometimes model polygenic risk better than binarized definitions. We compared two severity measures of suicidal thoughts and behaviors at the molecular and functional levels using genome-wide data. We used summary association data from GWAS of four traits analyzed in 122,935 individuals of European ancestry: thought life was not worth living (TLNWL), thoughts of self-harm, actual self-harm, and attempted suicide. A new trait for suicidal thoughts and behaviors was constructed first, phenotypically, by aggregating the previous four traits (termed "suicidality") and second, genetically, by using genomic stru

SUBMITTER: Quintero Reis A 

PROVIDER: S-EPMC10005939 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature