Study on the mechanism of aging-related erectile dysfunction based on bioinformatics and experimental verification.

ABSTRACT:

Background

The incidence of aging-related erectile dysfunction (ED) remains high in the elderly population, and has attracted the attention of the medical community. However, aging-related ED responds poorly to traditional treatments for ED, and its mechanism has not yet been fully clarified. This study sought to explore the potential mechanisms of aging-related ED based on bioinformatics and experimental verification.

Methods

A bioinformatics analysis was performed on data from the Gene Expression Omnibus database related to ED and aging, and the associated differentially expressed genes (DEGs) and signaling pathways were identified. Young and aged rats (n=8 per group) were included in the experimental verification study. Erectile function was detected by electrical stimula

SUBMITTER: Sun T 

PROVIDER: S-EPMC10005994 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature