Prognostic value of galectin-1 and galectin-3 expression in localized urothelial bladder cancer.

ABSTRACT:

Background

Galectin-1 (Gal-1) and Galectin-3 (Gal-3) are carbohydrate binding proteins with a wide range of biological activity, including regulation of cellular adhesion, proliferation, and apoptosis in solid tumors. Prior small studies have reported that Gal-3 expression is associated with progression of disease in urothelial carcinoma (UC), from non-muscle invasive UC progression to muscle invasive UC. We assessed Gal-1 and Gal-3 protein expression H-score utilizing a tissue microarray (TMA) created from 301 cystectomy specimens.

Methods

Immunohistochemistry for Gal-1 and Gal-3 was performed on TMA generated from tumor blocks from chemotherapy naïve cystectomy specimens. The variable of interest, H-score, was defined as the product of the percentage of cells staining posi

SUBMITTER: Zhu J 

PROVIDER: S-EPMC10005997 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature