Consistency and diagnostic accuracy of 4 assays in the detection of the total and free prostate-specific antigen

ABSTRACT:

Background

The lack of interchangeability among prostate-specific antigen (PSA) assays causes difficulties in clinical interpretation. The currently available mainstream assays for PSA were based on Western populations, but it is not clear whether these assays yield different results in prostate cancer (PCa) screening in Chinese populations.

Methods

A total of 163 men with a total PSA (tPSA) level of 2–10 µg/L scheduled for prostate biopsy were enrolled in this study. The levels of the tPSA and free PSA (fPSA) were detected by the Beckman (using the Hybritech calibration), Roche, Abbott, and Mindray (using the World Health Organization’s calibration). Methodological comparison were performed according to EP9-A3 of the Clinical and Laboratory Standards Institute, USA. With

SUBMITTER:  

PROVIDER: S-EPMC10006006 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature