Biomarker identification of immune-related genes in pheochromocytoma and paraganglioma.

ABSTRACT:

Background

Although we have a good understanding of the diagnosis and treatment of pheochromocytoma and paraganglioma (PPGL), the underlying pathogenesis and molecular pathways of PPGL need to be further studied. This study aimed to use bioinformatics to analyze the role of immune-related genes (IRGs) in the pathogenesis of PPGL.

Methods

GSE19422 and GSE60459 microarray data were obtained from the Gene Expression Omnibus (GEO) database. Differentially expressed genes (DEGs) were identified using the "limma" package in R, and genes overlapping with IRGs were screened using the "VennDiagram" package. A protein-protein interaction (PPI) network was constructed in the Search Tool for the Retrieval of Interacting Genes/Proteins (STRING) database, and the core genes were identifie

SUBMITTER: Wan GY 

PROVIDER: S-EPMC10006013 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature