Distinguishing Benign and Malignant Findings on [⁶⁸ Ga]-FAPI PET/CT Based on Quantitative SUV Measurements.

ABSTRACT:

Aim/purpose

Fibroblast activation protein (FAP) is overexpressed by cancer-associated fibroblasts. However, activated fibroblasts have been shown to play a significant role also in certain benign conditions such as wound healing or chronic inflammation. Therefore, the current study aimed to identify whether FAPI uptake might differ between malignant lesions and benign conditions.

Material and methods

We retrospectively analyzed 155 patients with various cancer types who received [⁶⁸ Ga]-FAPI-04/02-PET/CT between July 2017 and March 2020. SUV_max, SUV_mean, and lesion-to-background ratios (LBR) of FAPI uptake were measured in benign processes compared to malignant lesions (primary and/or 2 exemplary metastases). In addition, receiver operating c

SUBMITTER: Dabir M 

PROVIDER: S-EPMC10006041 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature