Induction chemotherapy reduces target volume drift in patients with locoregionally advanced nasopharyngeal carcinoma undergoing adaptive intensity-modulated radiotherapy: a retrospective cohort study

ABSTRACT:

Background

Adaptive radiotherapy (ART) provides real-time correction of the target and dose of radiation based on repeat computed tomography (CT) imaging and replanning during intensity-modulated radiation therapy (IMRT) and is important for locoregionally advanced nasopharyngeal carcinoma (NPC). However, repeat CT imaging and replanning are time-consuming and hinder the broader application of ART. The optimum dose and frequency of replanning time have been published in previous reports. The purpose of this study was to determine whether induction chemotherapy (IC) reduces target volume drift during IMRT, potentially reducing the replanning workload.

Methods

From January 2012 to December 2017, 40 patients with locoregionally advanced, nonmetastatic stage III–IVa NPC treat

SUBMITTER: Yan D 

PROVIDER: S-EPMC10006138 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature