Chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI) quantification of transient ischemia using a combination method of 5-pool Lorentzian fitting and inverse Z-spectrum analysis.

ABSTRACT:

Background

Chemical exchange saturation transfer (CEST) is a promising method for the detection of biochemical alterations in cancers and neurological diseases. However, the sensitivity of the currently existing quantitative method for detecting ischemia needs further improvement.

Methods

To further improve the quantification of the CEST signal and enhance the CEST detection for ischemia, we used a quantitative analysis method that combines an inverse Z-spectrum analysis and a 5-pool Lorentzian fitting. Specifically, a 5-pool Lorentzian simulation was conducted with the following brain tissue parameters: water, amide (3.5 ppm), amine (2.2 ppm), magnetization transfer (MT), and nuclear Overhauser enhancement (NOE; -3.5 ppm). The parameters were first calculated offline and st

SUBMITTER: Zhang L 

PROVIDER: S-EPMC10006163 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature