Parishin A-loaded mesoporous silica nanoparticles modulate macrophage polarization to attenuate tendinopathy.

ABSTRACT: Macrophages are involved mainly in the balance between inflammation and tenogenesis during the healing process of tendinopathy. However, etiological therapeutic strategies to efficiently treat tendinopathy by modulating macrophage state are still lacking. In this study, we find that a small molecule compound Parishin-A (PA) isolated from Gastrodia elata could promote anti-inflammatory M2 macrophage polarization by inhibiting gene transcription and protein phosphorylation of signal transducers and activators of transcription 1. Local injection or sustained delivery of PA by mesoporous silica nanoparticles (MSNs) could almost recover the native tendon's dense parallel-aligned collagen matrix in collagenase-induced tendinopathy by modulating macrophage-mediated immune microenvironment and pre

SUBMITTER: Zhu L 

PROVIDER: S-EPMC10006208 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature