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Domesticated HERV-W env contributes to the activation of the small conductance Ca²⁺-activated K⁺ type 2 channels via decreased 5-HT4 receptor in recent-onset schizophrenia.

ABSTRACT: The human endogenous retroviruses type W family envelope (HERV-W env) gene is located on chromosome 7q21-22. Our previous studies show that HERV-W env is elevated in schizophrenia and HERV-W env can increase calcium influx. Additionally, the 5-HTergic system and particularly 5-hydroxytryptamine (5-HT) receptors play a prominent role in the pathogenesis and treatment of schizophrenia. 5-hydroxytryptamine receptor 4 (5-HT4R) agonist can block calcium channels. However, the underlying relationship between HERV-W env and 5-HT4R in the etiology of schizophrenia has not been revealed. Here, we used enzyme-linked immunosorbent assay to detect the concentration of HERV-W env and 5-HT4R in the plasma of patients with schizophrenia and we found that there were decreased levels of 5-HT4R and a negati

SUBMITTER: Wu X

PROVIDER: S-EPMC10006216 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature

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Dataset Information

Domesticated HERV-W env contributes to the activation of the small conductance Ca²⁺-activated K⁺ type 2 channels via decreased 5-HT4 receptor in recent-onset schizophrenia.

OmicsDI is part of the ELIXIR infrastructure

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Dataset Information

Domesticated HERV-W env contributes to the activation of the small conductance Ca2+-activated K+ type 2 channels via decreased 5-HT4 receptor in recent-onset schizophrenia.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Domesticated HERV-W env contributes to the activation of the small conductance Ca²⁺-activated K⁺ type 2 channels via decreased 5-HT4 receptor in recent-onset schizophrenia.