Early effects of lurasidone treatment in a chronic mild stress model in male rats.

ABSTRACT:

Rationale

Stress represents a major contributor to the development of mental illness. Accordingly, exposure of adult rats to chronic stress represents a valuable tool to investigate the ability of a pharmacological intervention to counteract the adverse effects produced by stress exposure.

Objectives

The aim of this study was to perform a time course analysis of the treatment with the antipsychotic drug lurasidone in normalizing the anhedonic phenotype in the chronic mild stress (CMS) model in order to identify early mechanisms that may contribute to its therapeutic activity.

Methods

Male Wistar rats were exposed to CMS or left undisturbed for 7 weeks. After two weeks of stress, both controls and CMS rats were randomly divided into two subgroups that received vehicle

SUBMITTER: Creutzberg KC 

PROVIDER: S-EPMC10006266 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature