Anemia and Erythrocyte Indices Are Associated With Neurocognitive Performance Across Multiple Ability Domains in Adults With HIV.

ABSTRACT:

Background

Anemia is linked to neurocognitive impairment (NCI) in people with HIV (PWH), but its impact within specific ability domains, and in diverse populations with HIV, is uncertain.

Methods

Participants included 1339 PWH enrolled in observational HIV cohort studies with a mean of 3 comprehensive neurocognitive assessments over 30 months. Global and domain-specific neurocognitive function were assessed by the global deficit score and domain deficit score (GDS and DDS, respectively) or as GDS-defined or DDS-defined NCI (GDS ≥ 0.5, DDS > 0.5). Time-dependent associations of anemia or red-cell indices with neurocognitive function were evaluated by multivariable regression.

Results

The mean age at entry was 43.6 years (85% male, 23.9% Hispanic, 16.7% African ancestry

SUBMITTER: Okwuegbuna OK 

PROVIDER: S-EPMC10006328 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature