A fabricated hydrogel of hyaluronic acid/curcumin shows super-activity to heal the bacterial infected wound.

ABSTRACT: High risk of acute morbidities and even mortality from expanding the antibiotics resistant infectious wounds force indefinite efforts for development of high performance wound-healing materials. Herein, we design a procedure to fabricate a hyaluronic acid (HA)-based hydrogel to conjugate curcumin (Gel-H.P.Cur). The highlight of this work is to provide a favorite condition for capturing curcumin while protecting its structure and intensifying its activities because of the synchronization with HA. Accordingly, HA as a major component of dermis with a critical role in establishing skin health, could fortify the wound healing property as well as antibacterial activity of the hydrogel. Gel-H.P.Cur showed antibacterial properties against Pseudomonas aeruginosa (P. aeruginosa), which were examine

SUBMITTER: Khaleghi M 

PROVIDER: S-EPMC10006388 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature