Combination of natural polyphenols with a precursor of NAD⁺ and a TLR2/6 ligand lipopeptide protects mice against lethal γ radiation.

ABSTRACT:

Introduction

Effective agents that could confer long-term protection against ionizing radiation in vivo would have applications in medicine, biotechnology, and in air and space travel. However, at present, drugs that can effectively protect against lethal ionizing radiations are still an unmet need.

Objective

To investigate if combinations of natural polyphenols, known for their antioxidant potential, could protect against ionizing radiations.

Methods

Plant-derived polyphenols were screened for their potential ability to confer radioprotection to mice given a lethal whole-body γ radiation (¹³⁷Cs) dose expected to kill 50% of the animals in 30 days. Telomere and centromere staining, Q-FISH and comet assays were used to investigate chromosomal aberration, mic

SUBMITTER: Obrador E 

PROVIDER: S-EPMC10006514 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature