SCAP deficiency facilitates obesity and insulin resistance through shifting adipose tissue macrophage polarization.

ABSTRACT:

Introduction

Sterol regulatory element binding protein (SREBP) cleavage-associating protein (SCAP) is a sterol-regulated escort protein that translocates SREBPs from the endoplasmic reticulum to the Golgi apparatus, thereby activating lipid metabolism and cholesterol synthesis. Although SCAP regulates lipid metabolism in metabolic tissues, such as the liver and muscle, the effect of macrophage-specific SCAP deficiency in adipose tissue macrophages (ATMs) of patients with metabolic diseases is not completely understood.

Objectives

Here, we examined the function of SCAP in high-fat/high-sucrose diet (HFHS)-fed mice and investigated its role in the polarization of classical activated macrophages in adipose tissue.

Methods

Macrophage-specific SCAP knockout (mKO) mice were

SUBMITTER: Lee JH 

PROVIDER: S-EPMC10006517 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature