Muscle sympathetic nerve activity during pregnancy: A systematic review and meta-analysis.

ABSTRACT: We conducted a systematic review and meta-analysis to quantify the impact of healthy and complex pregnancy on muscle sympathetic nerve activity (MSNA) at rest, and in response to stress. Structured searches of electronic databases were performed until February 23, 2022. All study designs (except reviews) were included: population (pregnant individuals); exposures (healthy and complicated pregnancy with direct measures of MSNA); comparator (individuals who were not pregnant, or with uncomplicated pregnancy); and outcomes (MSNA, BP, and heart rate). Twenty-seven studies (N = 807) were included. MSNA burst frequency was higher in pregnancy (n = 201) versus non-pregnant controls (n = 194) (Mean Differences [MD], MD: 10.6 bursts/min; 95% CI: 7.2, 14.0; I²  = 72%). Accounting for the

SUBMITTER: Greenwall KM 

PROVIDER: S-EPMC10006587 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature