Characterization of glycometabolism and tumor immune microenvironment for predicting clinical outcomes in gastric cancer.

ABSTRACT: Recent evidence demonstrates that the reprogramming of energy metabolism can interact with the tumor immune microenvironment, thereby participating in the progression of cancer. In this study, multi-omics data of 2471 gastric cancer samples were used to identify tumor glycometabolism and its correlation with tumor immune microenvironment. A series of bioinformatic approaches were performed to establish a scoring system to predict the survival and response of chemotherapy and immunotherapy. Three glycometabolic subtypes and two immune clustering subgroups of gastric cancer were determined. We further established a Gluco-Immune Scoring system to quantify the cancer glycometabolic status and immune infiltration of individual patients. Patients with low Gluco-Immune Score were sensitive to adj

SUBMITTER: Shi J 

PROVIDER: S-EPMC10006618 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature