Optical Penetration of Shape-Controlled Metallic Nanosensors across Membrane Barriers

ABSTRACT: Precise nanostructure geometry that enables the optical biomolecular delivery of nanosensors to the living intracellular environment is highly desirable for precision biological and clinical therapies. However, the optical delivery through membrane barriers utilizing nanosensors remains difficult due to a lack of design guidelines to avoid inherent conflict between optical force and photothermal heat generation in metallic nanosensors during the process. Here, we present a numerical study reporting significantly enhanced optical penetration of nanosensors by engineering nanostructure geometry with minimized photothermal heating generation for penetrating across membrane barriers. We show that by varying the nanosensor geometry, penetration depths can be maximized while heat generated durin

SUBMITTER: Da A 

PROVIDER: S-EPMC10007193 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature